"from genes, synapses and circuitries to pave the way for novel therapies"
at Faculty of Medicine, University of Lisbon
Highlights:
. . .
"European Researchers Night" Science Education | 29 September 2023 in Lisbon
@immolecular scientists engaged with society to talk about the functions of different brain cells and their impact in diseases such as epilepsy
. . .
28 February 2023 | Rare Disease Day
"rare is many, rare is strong rare is proud"
Our Mission:
"Promote Collaborative multidisciplinary & translational research in epilepsy"
"Promote public awareness on epilepsy caregiving &
research to patient communication"
Who are we?
4 European Research Institutions came together to build EpiEpiNet:
About the cover: Adaptation of a microscopy image of a mouse brain section stained with the nuclear marker DAPI. A mosaic containing the hippocampus is shown.
Acknowledgement: Leonor Rodrigues, Ana Sebastião Laboratory, iMM
Our Funding:
Past Events
1-2 June 2023 | Workshop in Lund, Sweden
- "Use of human epileptic tissue from epilepsy surgeries as a validation step of findings in animal model"
Workshop programme
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17-19 April 2023 | Workshop in Lisbon, Portugal
- "Responsible Research & Innovation"
imm scientists & staff participated in Responsible Research&Innovation course by @ChaperoneOnline.
Participants discussed the importance of Gender Equality,Public Engagement,Open Science,Science Education, Ethics&Good Governance, the 6 pillars of RRI.
. . .
23-24 September 2022 | Meeting in Lisbon, Portugal
- 3rd EpiEpiNet Annual Meeting
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19-20 September 2022 | Workshop in Rome, Italy
- "Synaptic Function in epileptic disorders: from basic research to clinical implications"
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24 July 2022 | At Doca Lisboa for the General Public25 July 2022 | At iMM for Researchers
- Raising awareness on epilepsy & Building the future of epilepsy research
(in cooperation with "Sail for Epilepsy" & Liga portuguesa contra a epilepsia)
Sail for Epilepsy on national news - see here
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- "Optogenetics and chemogenetics in epilepsy research"
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25 March 2022 | Round Table in Lisbon, Portugal- "Epilepsies in a school context"
What is epilepsy? How to detect and act in case of seizures? How to communicate?
A scientist, a neuro pediatrician, a nurse and a psychologist get ready to talk! The resuls?
. . .
23 & 24 Nov 2021 | Workshop- "Neuropathology of epilepsy: from experimental models to human disease tissue
In the 1st Workshop organized by Professor Eleonora Aronica and Professor Erwin van Vliet (Amsterdam Medical Centre) we used a novel digital pathology platform to learn interactively about histological hallmarks and seizures, epileptogenesis and its consequences.
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27-Sep-2021 - 01-Oct-2021 | Summer School in Costa da Caparica, Portugal- "Trends and challenges in epilepsy research"
Held as an hybrid event, the in-person event took place in Portugal, surrounded by the beautiful Autumn sun, waves and beaches of Costa da Caparica. This allowed us to discuss science and build bridges to boost research in epilepsies in an outstanding and relaxing environment.
Publications
2023
- Research Article - International Journal of Molecular Sciences
Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of Mecp2 Heterozygous Mouse Females (online) Authors: Catarina Miranda-Lourenço, Jéssica Rosa, Nádia Rei, Rita F Belo, Ana Luísa Lopes, Diogo Silva, Cátia Vieira, Teresa Magalhães-Cardoso, Ricardo Viais, Paulo Correia-de-Sá, Ana M. Sebastião, Maria J. Diógenes
- Research Article - Neurobiology of Disease
Cognitive comorbidities of experimental absence seizures are independent of anxiety (online) Authors: Mariana Neuparth-Sottomayor, Carolina C. Pina, Tatiana P. Morais, Miguel Farinha-Ferreira, Daniela S. Abreu , Filipa Solano, Francisco Mouro, Mark Good, Ana M. Sebastião, Giuseppe Di Giovanni, Vincenzo Crunelli, Sandra H. Vaz
2021
- Research Article - Stem Cells Journals
Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor (online) Authors: Filipa F. Ribeiro, Filipa Ferreira, Rui S. Rodrigues, Rita Soares, Diogo M. Pedro, Marta Duarte-Samartinho, Rita I. Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Solá, Helena Mira, Ana M. Sebastião, Sara Xapelli
- Research Article - Current Issues in Molecular Biology
High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats (online) Authors: Sara L. Paulo, Catarina Miranda-Lourenço, Rita F. Belo, Rui S. Rodrigues, João Fonseca-Gomes, Sara R. Tanqueiro, Vera Geraldes, Isabel Rocha, Ana M. Sebastião, Sara Xapelli, Maria J. Diógenes
- Research Article - Frontiers in Neurology
Generalized Fast Discharges Along the Genetic Generalized Epilepsy Spectrum: Clinical and Prognostic Significance (online) Authors: Emanuele C. Irelli, Francesca A. Barone, (...) Anna T. Giallonardo, Francesca Izzi, Carlo Di Bonaventura
- Critical Review - Epilepsy
Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging (online) Authors: Erwin A van Vliet, Nicola Marchi
- Research article - Journal of Neurodevelopmental disorders
Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period (online) Authors: Anatoly Korotkov; Mark J. Luinenburg; Alessia Romagnolo; (...) James D. Mills; Eleonora Aronica
- Research article - Brain Sciences
Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy (online) Authors: Pierangelo Cifelli, Silvia Di Angelantonio, (...) Eleonora Aronica, Gabriele Ruffolo, Eleonora Palma
- Research article - Frontiers in Neurology
Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence (online) Authors: Federica Avorio; Federica Avorio; (...) Anna Teresa Giallonardo; Carola Severi; Carlo Di Bonaventura
- Research article - Epilepsia
Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia 2B brain lesions (online) Authors: Victoria-Elisabeth Gruber, Mark J. Luinenburg, (...) José Pimentel, (...) Eleonora Aronica, and Angelika Mühlebner
- Research article - Cellular and Molecular Neurobiology
Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex (online) Authors: Anika Bongaarts, Caroline Mijnsbergen, (...) James D. Mills, Eleonora Aronica
- Research article - Neuropathology & Applied Neurobiology
Balloon cells promote immune system activation in focal cortical dysplasia type 2b (online) Authors: Till S. Zimmer; Diede W. M. Broekaart; (...) James D. Mills; Eleonora Aronica
- Research article - Neuropathology & Applied Neurobiology
MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis (online) Authors: Anatoly Korotkov; Nam Suk Sim; (...) Eleonora Aronica
- Research article - Brain Pathology
Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress (online) Authors: Till S. Zimmer, Anatoly Korotkov, (...) Eleonora Aronica, James D. Mills
- Methodology article - JoVE
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures (online) Authors: Cláudia A. Valente; Francisco J Meda; Mafalda Carvalho; Ana M. Sebastião
- Research article - Stem Cells
Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor (online) Authors: Filipa F. Ribeiro, Filipa Ferreira, (...) Ana M. Sebastião, Sara Xapelli
- Review article - Pharmacological Research
Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder (online) Authors: Joana I. Gomes, Miguel Farinha-Ferreira, (...) Joaquim A.Ribeiro, Ana M.Sebastião
2020
- Review arcticle – International Journal of Molecular Sciences
Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy (here) Authors: Diogo M Lourenço*, Leonor Ribeiro-Rodrigues*, Ana M Sebastião, Maria J Diógenes , Sara Xapelli *contributed equaly to this work
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anaseb@medicina.ulisboa.pt (project coordinator)